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The antidepressant bupropion hydrochloride does not significantly increase longer-term smoking cessation rates for some patients, despite several recent studies touting its use for this purpose, Dr. Joel A. Simon and his colleagues reported.
In a randomized, blinded trial conducted in the San Francisco Veterans Affairs Medical Center of 244 veterans who were moderate to heavy smokers, 121 subjects received a 7-week course of bupropion and 123 received placebo. All subjects were given 2…